Not from Manchester (actually I think there was a flight on Singapore, but you still had to fly via Frankfurt), that's the point.
Sure you can fly on Singapore and (used to Qantas) from Heathrow, that's a hub to hub flight, and both are/were on A380s.
Fly from Dublin to Singapore you're going via a hub -- Healthrow, Frankfurt, Dubai, doesn't matter.
Fly from Delhi to Manchester you're going via a hub
Fly from Edinburgh to Muscat you're going via a hub
The 787 and A350 perform well for gulf carriers in flying to places like Edinburgh, where Emirates I think were doing 2 flights a day. The A380 doesn't work for these region-hub airports, but we still have Spoke-Hub-Spoke on long haul, and will for the forseeable. What we don't have (much) is Spoke-Hub-Hub-Spoke, as the 787 and A350 have made it more economic to serve long haul spokes from a single hub.
I mean there's a number of other airlines you could fly on - Singapore Air, or Qantas (I'm pretty sure they offered that as a fifth freedom flight)